Wednesday, November 13, 2013

PANDAS...Great strides made in research.

Recently, a scientist whom has been researching Pandas was able to show empirical evidence that Pandas does indeed exist.

This is second hand information, it might contain some inaccuracies, however, it transcends the main important idea.
He cross bred white mice and created a Hybrid that have autoimmune deficits.
He then injected them with T cells derived from Panda's serum that is thought to be the culprit behind this disorder. The mice all started to show Pandas symptoms. They went from calm to a hyperactive state, frenetic, and aggressive, also doing the same motoric movements over and over again.
He then treated them with IG antibodies. (The same treatment that Everett received last June).  They all returned back to normal.
He then did brain biopsies on the mice.  He found that the T cells had indeed made their way across the Brain Blood Barrier and into the Basal Ganglia, causing an inflammatory response that is not able to be viewed by an MRI, or detected by a blood test.  The controversy over Pandas is that nobody could prove that the BBB could be breeched. He has now proven this.
He did timeline linear autopsies to see how long these antibodies would remain in the brain before leaving. (full recovery).  Timeline showed several months to leave the brain if not re-infected. The conversion to humans is up to 6 years.
Because he was able to replicate this by injecting  Pandas serum, it  showed that once the Pandas disorder is tripped off, all future T cells mfg by the immune system have what is called a "working memory". Meaning, if a child has a cold, stomach flu, loses a tooth, stress, anything that causes an autoimmune response in any way and T cells are mfg, they will go after the basil ganglia as well as the foreign enemy, especially if the BBB has not had adequate time to heal and close. Thus, we see the remitting/relapsing pattern in children.
The good news: All research studies reveal that  All children who have been treated young, like Everett, recover fully and lead healthy lives. It may take 1 to 2 years for the effects of IVIG to do their things, but the prognosis is promising!!! 
His work is in the process of being published by the scientific journals and undergo peer review.
Translation: We are not all crazy.

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